My gastro gave me a script for prucalopride but I won't take it. Afraid it will affect my ventricular tachycardia. My cardiologist told me better to stay away from motility drugs. Linzess caused tons of unbearable pain. I use Senokot. It works. It aggravates my irritable bowel but it's the best of the worst for me. My problem got worse after starting Prolia injections for osteoporosis.
Chronic unrelenting constipation is just a dreadful condition to deal with.

I was stable on my major depressive disorder and my gut was ok. But when my insurance company declined to pay $1.00 for me to continue that medication and required me to try and fail 3 other like medications, all with more side effects, before they would reconsider allowing me to continue the effective medication. So now over a year later I have become unable to function , lost a really good paying job after working as a RN for the company for 22 hyears. There are many docotrs who blow you off if they know you have a diagnosis of depression. This included
the GI PA who told me that it was all due to the brain gut conection. So I finally took him by the hand and convinced with the medical information that their office had that he would appease me by ordering a Cat Scan of the abdomen/pelvis. He assured me it would all be fine. Well he callede 3 days later after recieving the CT results to let me know it showed a gallbladder full of stones and one that was impacting the neck of the gallbladder. I asked him if he fully underastood the agony I had endured for the past 5 month. He had NO reply. My goodness my weight had gone from 167 lbs to 119 today. I was begging God to have mercy.