Hi Amanda. Thank you for your reply. I started getting constipated when I was about 22 years of age. I am 43 now. I had a colonoscopy after my 2 children were born (30 y.o.) and they couldn't complete it. I was then diagnosed with a redundant colon. At about that time I was also diagnosed with Bipolar Disorder and put on medication. Nothing further was done with my bowel up until about 5 years ago when I had a colon transit study which showed a slow transit bowel, which didn't surprise me at all since I could go up to 15 days without even a "pebble". Increased dose of S. Pelligrino but over time it was making me unbelievably nauseous. I put up with it until I had a hysterectomy and with all the adhesion's and endometriosis (I never knew I had it) they removed I thought it would make a difference but it didn't. I tried a few GI specialists and eventually found a Colo-rectal specialist. We redid the colonoscopy (good result), transit study (very slow) and anometry (rectal muscles are fine). So my doctor wants to do everything he can before taking my bowel. I already take docusate 200mg/daily and 4 sachets/daily of Movicol, and 12 days ago I started on prucalopine 2mg/daily (Resotrans or Motegrity). That has done nothing except one small movement which, in all honesty, happened when I increased my Movicol. I take a number of psych meds and I know they slow movement however my constipation started before my bipolar diagnosis and I have since found out my Grandmother also had this issue and her mother died of a paralytic illeus and twisted colon in her late thirties, so I am guessing she also lived with this. I have only been eating a self imposed soft or liquid diet and graze throughout the day so I have lost a bit of weight. I am just tired all the time. I see my specialist again next week. I live in country Australia and my specialist is 4 hours away.