My incredible Mayo gyn/oncology/surgeon claims this test is a better indicator then CA125. When I was first diagnosed myHE4,S was high (722) and with each chemo session, I watched it come down finally to 54 so we knew chemo was working. My local oncology does not use this test, but now he does! It is the same blood draw (hope you have a port) so please ask for it. I get both these tests every two weeks.