Hi gingerw,
The new combination of keytruda and lenvatinib was FDA appoved on September 17, for those with no mismatch repair, and no tumor markers that can be targeted.
Keytruda is given commonly as an infusion, and does not have too many side effects.
However the lenvatinib is a multi kinase inhibitor. Side effects I have experienced are-
High blood pressure, had to start medication for it.
Extreme weakness and fatigue, muscular pain, joint pains.
Loss of appetite, abdominal discomfort, severe constipation, painful cramping.
Increase irritability and am becoming intolerant to loud sounds, and angry, and mentally not all there. I stand in front of the fridge, and have no idea why I opened it, poor memory, confusion. The cognitive side effects are most distressing.
Itching in my hands and feet, and occasional pain.
Neuropathy continues, and this maybe because of the previous taxol treatment.
I could go on, but you get the idea.
I will do 2 cycles and then get the scans, hope it shows improvement. I will discontinue, if it does not.
Hope all is well with my sisters in this group. Love and best wishes,
m1b1r9.