@vetnyregr My Dr said she wrongly put me on them daily for 2 years, it should have been daily for cavities, she had not told me I had cavities for 2 years or I could have corrected her. Yes its a very long time on the big 3 but only a year on Amikacin inhaled, no I haven't had infused at all. My cavities did close on their own but they left a small scar, which I guess would also happen with surgery. I hope yours take alot less time, and hope you are on daily! The big three and Amikacin is a good combination.