Because side effects differ so greatly for every person and for every drug, I hesitate to state my own particulars, which may not apply to others, and prefer to emphasize trying the different medications in hopes that one works for you.

Evista/Raloxifene, which is the least effective of the 5 ( the other 4 being Tamoxifen, Armidex/Anastrozole, Femara/Letrozole, Aromasin/Examestane) has been ok for me now that I have strategies in place to reduce the frequency and severity of leg cramps when I sleep. I stretch my calves and lower legs often during the day, before bed, and if I have been particularly active or doing new activities, I get up in the middle of the night to stretch. No other side effect for me that I am aware of besides leg cramps. And I was prone to leg cramps before taking the drug, and my mother gets leg cramps too, starting at about the age I am. The oncologist told me that my weight and blood pressure mean the risk of blood clots are not elevated for me by taking Evista/Raloxifene.

Best wishes to you all in your decisions. It would be great if a better alternative without frequent side effects were developed.