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SERMs and AIs - Choosing not to take them

Breast Cancer | Last Active: Aug 29, 2019 | Replies (20)

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@bpickartz

I followed much the same path. My oncologist came recommended by gynecologists (who happen to be my best friends) and by friends who had worked with him during their surgeries. I am confident that he's got my best interest in mind. If I wasn't dealing with both a history of blood clots and heart issues, He understood that my cardiologist wasn't comfortable with radiation and agreed with him, so a lumpectomy was ruled out.

The side effects I might be able to deal with but those, combined with my history and existing health concerns, have me leaning toward forgoing these drugs. Bone loss, heart issues, and blood clots are just too scary. Tuesday my husband and I sit down with the doctor. If the chances of reccurence aren't high, I'm going to decline. I agree that no one gets out alive, but I want my final years to be as good as they can be.

My mother was diagnosed at the same age I am (68). She had a mastectomy, no radiation or chemotherapy, and no long term therapy. I'm not sure that was even an option 34 years ago. She lived well for 20 more years and didn't have cancer when we lost her.

Unless the doctor can offer a compelling argument and after a second consultation with my gynecologists/friends, I'm leaning toward refusing a SERM or AI.

Can I ask what you take, how long you've been on it, and what the side effects are? Learning more about what to expect from real people will help me make a decision. Thanks much.

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Replies to "I followed much the same path. My oncologist came recommended by gynecologists (who happen to be..."

I was on Anastrozole for about 4 months and I broke out in some pretty severe hives. My doctors aren’t sure why I broke out with skin issues, but hives are a rare side effect of Anastrozole. So my oncologist switched me to Tomoxifin, 10 mg., and I’ve been fine. My worst side effect of both Anastrozole and Tomoxifin has been brain fog, and difficulties with memory. By googling those drugs and learning all I can about them, I have found that some memory and cognitive function problems are indeed a side effect. Since my cancer was a very slow growing type, my oncologist gave me a break from these drugs for about 4 months to see if it makes a difference. It’s night and day where my cognitive function is concerned! I absolutely hate not being able to think clearly!! I see Dr. Saundra Buys, my oncologist, again at the end of September and we’ll discuss what to do then. But if she feels that going back on meds. at that time is in my best interest, then I’ll follow her advise. She may advise an alternative medication, or some other solution. But I trust her judgement and know she has my best interest at heart. Cancer sucks!!!