@newgranny @newgranny Has your oncologist offered you Tamoxifen? It is not an aromatase inhibitor. Mine suggested if I cannot tolerate the AIs that I would need to be on that as I have a neuroendocrine component of cancer and have to be on something. Unfortunately, it does come with side effects. For your osteoporosis, have you had Zometa infusions? I came to cancer already with osteoporosis...had my first Zometa infusion a few weeks ago and am told I need to do these every 6 months for 3 years. Don't give up and don't let anxiety take over...get outside in the fresh air and sunshine. When I start to get upset, I think of everyone that needs me and keep pushing forward.