I am very glad you picked up this inquiry. Have you had an appointment with your oncologist? He will probably discuss it with you. It is very interesting that your numbers are so much different than mine. My oncologist says that these marker numbers change all the time. I think a lot depends on your type and stage of cancer. As I said, other than with the surgeries, my CA 15-3 has never been tested. If this is not concerning to your Dr, then it shouldn't be to you. Please continue to respond to this as time goes by.