Bonnie, I have taken several of the PPI drugs you are concerned about for more than 10 years along with carefully controlling my diet and life style. Of course I am also concerned about the possible long term effects. But I am also concerned with the herd end now problems of trying to live with acid reflux and the possible esophageal damage resulting without the medication. I have not tried any supplements as an alternative. I don’t Have the patience to experiment with these options—various combinations and dosages. So I am gambling on continuing to take the PPI at the lowest possible dosage that works for me and watching my diet. Maybe surgery will have to be my eventual solution. But one day at a time. Good luck to you whatever you decide.