Hi, @100154 - you asked about the comment in the post from @geronimo1 about an oncologist stating that tamoxifen, letrozole (Femara) and anastrozole (Arimidex) only make a 1% difference, if tolerated. We are not medical professionals on Mayo Clinic Connect and don't offer medical advice, but other members who have taken some of these medications can offer their input from their experiences. Glad you've connected with @cancersucks. Hoping that @buckimom @lisman1408 @trixie1313 @jeannie53 and others also will offer their thoughts.

Will you share any of your experiences with these medications, @100154, and how you feel they have gone for you?

Yes it is true for some non estrogen based cancers, but depends on individual.