Well from my research, anxiety and depression are not uncommon after major surgery, as is insomnia. My surgeons office Said that insomnia is their number one complaint after total knee replacement. They also said that most prescription drugs will not work. At this point, I think the main cause of my anxiety and depression is the sleeplessness. Of course sleeplessness is also a consequence of anxiety and depression! Ugh! Thanks for responding to my post.