@nanners012910 Welcome to Mayo Clinic Connect. Anytime there is a new medication on the market there is a period of adjustment while people put it into practical use. What I have found over the years is that what works for one person may not work for the other person. If you're comfortable please tell us a little bit more about yourself and the types of medications that you have used, and other ways you have battled your depression? Here at Mayo Clinic Connect we're always interested to hear what has worked for different individuals. This way we are able to expand our knowledge base and also consider alternative things in our own personal lives. None of us are medical professionals; we are all patients.
Ginger

For me, relying on my own feelings on taking meds that worked or don’t work well enough was the wrong choice. I eventually found a GP that knows me very well and knows what med is working and which one is not. I hoping the best for you.

@nanners012910- Good morning and I'm glad that you found our site. I understand your frustration in finding the right drugs for your depression. I have PTSD and have also gone through many trials before I found the right one. I am one Zoloft and Brupropion and CBD oil. I also exercise and I have to tell you that was a game changer for me when I started back exercising. I know that when you are really down, down ,down it's the last thing you want to do but it's also the best thing to do. Can you grab a friend who will be tough, but gentle with you to help with this process?

https://www.nbcnews.com/health/health-news/caution-urged-over-use-fast-acting-version-ketamine-depression-n1016176
When I see Miracle Drug every red flag in my vicinity goes to full alert. There are no miracle medicines, they either work or they don't. There is no divine power that selects which one is right for you and which aren't based on your experiences with it.
All are addictive and will take a lot of slow work to get off them. You probably have experienced this. I know that if I decide not to take mine anymore my depression will return so I have no plans on ever stopping.
But some antidepressants are more dangerous than others and I would classify Ketamine as one to be very very careful of. It's the same type of drug that Michael Jackson died from.
https://www.nbcnews.com/health/health-news/caution-urged-over-use-fast-acting-version-ketamine-depression-n1016176

Have you been exercising, being careful to eat as cleanly as possible and sleeping well?

If you would've be so kind and report back on results of this nasal spray. Ketamine has been recommended but was told that I needed to be monitored for any side effects in hospital setting and that this med was not covered by insurance. Good luck to you!