Hi.....I am new to this site....I do read all the posts but have never participated....I was diagnosed with MAC and Bronchiectasis four years ago... I took the Big 3 for a year . Then a year ago my FL pulmonologist did a Broncoscopy and found that MAC had returned....He did not put me on the antibiotics again.....but albuterol twice a day....In July I had blood in my mucus and coughing more than I ever had....Ended up going to the Cleveland Clinic in August....My doctor there put me on the 7% saline solution twice a day along with albuterol...Have a say in over a week my mucus was clear and I wasn't coughing or clearing my throat as before......Hope you give it a try....It worked for me...