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Negative sputum results without treatment

MAC & Bronchiectasis | Last Active: Dec 12, 2019 | Replies (103)

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@pfists

Hi all
I just wanted to post this article on Mogradex
It's in the pipeline with testing being done for NTM patients to use with or without antibiotics.
It enhances your own immune system without the the toxic side effects of antibiotics.
Have any of you heard about this? It is another to keep our eyes on like the nitric oxide treatment.
Here is a link
http://boston.big3bio.com/2018/04/02/spotlight-qa-rob-neville-ceo-savara-pharmaceuticals/
Here is part of the article:

Molgradex is an inhaled formulation of recombinant human GM-CSF. GM-CSF is not an antibiotic. Rather than targeting bacteria directly, GM-CSF stimulates the innate immune system in the lungs. The attraction of this approach is that we expect it can be used both with or without antibiotics and that the mechanism will not be affected by antibiotic resistance by the bacteria.

What do study results indicate so far?

Neville: In animal studies, GM-CSF has been shown to kill NTM with similar efficacy compared to commonly used NTM antibiotics, and the simultaneous use of GM-CSF with antibiotics may further improve the antibacterial effect.

Shari

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Replies to "Hi all I just wanted to post this article on Mogradex It's in the pipeline with..."

@pfists Shari, That is very exciting news. It sounds promising!

@pfists Thanks for that info, fingers crossed!

@pfists Thank you posting this Shari. This does sound promising, lets pray it works!