I’ve taken an array of anti-depressants over the last 30 years, and with one exception, they have addressed my depression issues. I have also taken anti-anxiety medication, which has done its job. I have had weight gain from all of them, but that problem is better than depression & suicidal ideation. The unfortunate part of the depression treatment protocol is that , at least in my case, one never gets “well” and the problem goes away. That serves to be depressing in its own right.