Hello @boo55 -- I know it must be frustrating not being able to sleep. I'm tagging our moderator @ethanmcconkey to see if we should combine your post into the following discussion where @popolopo is asking the same question and you can meet @coralbells1 @jeanne51 @elwooodsdad and @petangelkat1 who also have discussed Cymbalta in a post.

> Groups > Chronic Pain > Cymbalta
-- https://connect.mayoclinic.org/discussion/cymbalta-2/

Has your doctor offered any suggestions to help with the sleep?

Hi, @boo55 - how are things going with the sleeplessness you were experiencing from the duloxetine (Cymbalta)?

@boo55, Good afternoon. I am grateful for the relief that Cymbalta has given me from the uncontrollable anxiety that was taking over my life. Although my PCP suspected that the neuropathic pain was causing neurobehavioral issues including memory loss, it was confirmed by 4 hours of neurobiological testing. The bottom line....my pain was creating anxiety and the more anxious I became, the greater the pain. It was a huge dilemma for me. I had withdrawn from a volunteer marketing role in the community. I could not play mahjong or other distracting games unless someone at the table helped me remember what was happening next. I had some bouts with suicide. We approached it slowly with Cymbalta because, like you, I am sensitive to meds. Started with 20 mg for a month, then 40mg for the next month and now 60 mg. We decided that morning would be the best time to take this med. That solves the sleep issue and helps me when I need it most...during the daytime. Hope this helps.....have a safe and pain-free day. Chris

May I suggest Trazadone for sleep. It is an Antidepressant taken before bed. I sleep through the night. Have been taking for a long time, for me no side effects that I know of. I took Cymbalta for 1 day. I have Thyroid Autoimmune Disease that has effected me for years, Uticaria I was in remission until I took the pill. Incase anyone has same Autoimmune Disease thought I would add that.