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Can Gabapentin make neuropathy pain worse?

Neuropathy | Last Active: 2 days ago | Replies (374)
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@helennicola

Hi James, I was originally prescribed a low dose to be taken 3xday which left me unable to remember anything so after a few days I tried taking only 200 mg. at bedtime. It has worked fine for me for 2 yrs. increasing recently to 300 mg. Strangely, I tried upping to 400 mg. at bedtime when I was having a bad day and found it didn’t really work any better so I went back to the 300 mg. During the day I found that NSAIDS or CBD salve help if needed. It seems that doctors think more is better, I read somewhere that often a lower dose of gabapentin works better for some. Helen

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Replies to "Hi James, I was originally prescribed a low dose to be taken 3xday which left me..."
sunnyflower | @sunnyflower | May 14, 2020

Hello Leonard, just an FYI, Gabapentin has a very short half-life (5-7 hours) thus most take it three times per day. Warm regards, Sunnyflower

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jamesinsonoma | @jamesinsonoma | May 14, 2020

Hi Helen, My PCP increased my dose from 300mg Gabapentin 3x/day to 600 mg 3x/day, but not all at once, because the 300 was not reducing my pain. The 600 actually increased my pain. Now I'm tapering back to 300 3x/day with the goal of eliminating Gaba entirely. According to my neurologist, some if not all of my foot pain was due to a pinched nerver at L5/S1. Surgery 2 months ago released the nerver which, I pray, is healing. I see the neurologist in June to re-evaluate the neuropathy and maybe redo the nerve Conduction Velocity, NCV, test that showed a mild PN 3 months ago. The level of pain I've had since starting Gaba has been extreme and in no way would I describe it as mild.
James

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