@dakotarunner I had my Whipple on June 5 of 2014. The surgeon removed most of my pancreas, 1/3 of my stomach and my duodenum. What was left of my pancreas was so bad that the surgeon did not reattach it to my digestive system. I was diagnosed as Stage 2b. Cancer was found in the tumor on my pancreas and in 1 lymph node. I was released from the hospital on June 11 and started chemo on July 22. It was 5 years ago, but if I remember correctly, I was given Tylenol, an antihistamine, a steroid, anti-nausea medicine and finally gemzar (gemcitabine). I usually took more anti-nausea medicine at night on the day of my chemo. I did this for 3 weeks and then had one week off. The treatment lasted for 6 cycles. After my first chemo, I went to work. That only happened once. After every other chemo treatment, I went home and slept. It was the antihistamine that made me tired. The chemo never made me feel very sick. After every 3 chemo treatments, I was given neulasta. For me, that was worse than the chemo. My legs just above the knees just ached from the neulasta. As far as fatigue, there were days that I felt good so I got ready for work. That effort wore me out and instead of going to work, I sat down in my recliner and slept until noon. Your local oncologist will be able to tell you about your options for treatment. I hope things go as well for you as it did for me.