I have been on Zytiga (enzalutamide) for almost a year and it continues to work for me. What side effects did you experience? How long were you on it? I fully expect it will stop working for me at some point and am interested in learning more about potential future treatments. I have not heard anything about Lutetium so share an interest in what others may know. In the meantime, try to stay positive (I know how hard that can be, but it is essential) listen to your doctors and do what research you can. I look forward to others responses to your question.