We have not gone to chemotherapy yet. Bicalutamide worked in conjunction with Lupron for most of a year. Enzalutamide is very expensive but seems to be working thus far. I started getting Zolodrondric Acid infusions in April to help strengthen bones. It is a monthly infusion so another comes Thursday. It's hard to say one drug is better than another because so much depends on the specifics of each individual case. No two A Like (that's what I call my woodshop projects also). I have great faith and trust in my oncologist and I understand how he makes decisions based on established protocols so I follow his lead.