Each man reacts differently to side affects from Lupron. It took about 2 weeks for me. The best defense against the S.E.’s is exercise. I walk and workout not to build muscle but trying to maintain my muscle’s. I am a Gleason 9 with a lot of bone Mets. I have been on Lupron, Zytiga, Zometa and Prednisone for a year. Good luck on your journey.

Replying to @frankstags
First hot flash for me was probably about two weeks after the Lupron shot. They have continued at seemingly random times.