Hi, @mdavis1240 - welcome to Mayo Clinic Connect. You may have noted I moved your post here to an existing discussion of desvenlafaxine (Pristiq) so that you can connect with others who have taken this medication.

Hoping that members like @daphnesioux @sandiegan1972 @mominfo867 @eburning @steve1960 will have some thoughts on how long it might take to feel the effects of this medication.

I did note that in this Mayo Clinic article on desvenlafaxine https://www.mayoclinic.org/drugs-supplements/desvenlafaxine-oral-route/description/drg-20071583, it says, "You may have to take desvenlafaxine for several weeks before you begin to feel better."

I have noted with antidepressants personally (though I haven't take desvenlafaxine) that it can take up to 2-3 months to feel the full effect of the medication. It's a bumpy process to get through, I've thought, for sure.

What symptoms of the generalized anxiety disorder (GAD) and depression are your particularly looking to get under better control?