@didi09 @captainanxiety8 I have chronic myofascial pain and some pain sensitization and also occasional twitches (and some in the distant past). I believe it is excited nerves behind all of those. The itching is, quite possibly, a sign of “nerve pain”. Small pain receptors are unmyelinated (as are your autonomic nerves) so they are irritated more easily. I believe diet and exercise will help. Turmeric, all manner of flavonoids ( I like ORAC green energy powder), higher vitamin c with doses throughout the day help me, I think. I was able to get off nortriptyline (a tricyclic antidepressant which helps with nerve pain). I had muscle pain and enthesopathy ( pain \ sensitivity) at attachments and some burning/tingling and sciatica at one time. I’d take a low dose nortriptyline in the afternoon to avoid insomnia. If you do need something for the itching try nortriptyline or cymbalta at low doses. Some other people mentioned lyrica - I’d stay away unless the others won’t work. BTW, one of the side effects of nortriptyline is fasciculations. If possible, I’d try other diet changed first if you’re willing. It helped me at one time but I’m glad I’m off it.

I believe I also have a problem with too much fibrin (the blood clotting protein) deposition (or something like that which forms amyloid like deposition). So I also take some enzymes called nattokinase and serrapeptidase in between meals. Small nerve fibers might be more irritated by fibrin deposition. The enzymes help me. About 10% of people can’t tolerate them. If you have blood clotting disorders they are counter indicated. Many supplements can change blood pressure- so monitor that. It might be worth a try.

You may never know what is causing the fasciculations. However, consider researching neuropathy and adjust your diet accordingly as there are supplements and dietary changes (like adding healthy fats) that can help and there often is a tie in with gut health, too. You may either reverse it or at least minimize symptoms with the right diet changes. Good luck.