@buckimom– I'm feeling like a broken record here, weighing in with the same thing so many times, but I'm waiting for my oncologist to return from her vacation so I can get her advice. I'm having such pain everywhere from the Arimidex, I want to try going off of it for a one month test to make sure that's whats causing the pain. But I want to be sure that one month without the Arimidex won't put me at risk for a recurrence. If it IS the Arimidex, then I don't know where to go from there. It sounds like Letrozole is NOT the answer either, and I'm not sure about Tamoxifen. I've been on Arimidex for almost a year and a half, and if I have to tolerate this for another 3 years, I will, but sheesh!!