@tammyp @francine6829 - From what I've read so far on this and other sites, pretty much all the AI drugs have some potent side effects I've been on Arimidex for 14 months. I've preciously listed my side effects here and I think I just have to stick with it for the 5 years. I don't like to take Ibuprofen much, but I do when the pains get intolerable.