Hi Karen, I have had some success, but sooo many side effects. I have lost everything due to a lot of poor choices, bad luck, poor timing and anxiety and on and off panic attacks and on and off agoraphobia do not help. I had a Family that didn't say much when I was really suffering in my twenties.. My Psych wanted to put me on Trintellix.. I said no.. my Twin was on the former version Brintellix and went nuts with anger and aggression. I was leaning towards Vibrid. I need to walk around more.. hard when you feel like you cannot even get out of the apt much and feel and look awful and the whole community knows you don't have a reg. job.. My appearance reflects the total sadness, anger, blank stare. My Twin Sister tells me to just kill myself. Neurontin is pretty awful. Sorry Latuda stopped working for you. Thank you for responding. My Twin also has depression and anxiety and yet her Boss understands..