the medscape interactions checker says there are no known interactions. I have taken the two together without issue, except maybe drowsiness. but again I am not a doctor.

@jadillow - we aren't doctors or pharmacists. Please check with your doctor.

@jadillow: To answer your main concern about taking Wellbutrin (or Bupropion) and Clonazepam, I do. It looks like you've had plenty of feedback about tapering off Wellbutrin, so I'll just address your most recent question. My mental health doctor has prescribed the two together, and she is not my primary care physician, so I trust she is aware of adverse reactions in regard to medications for depression, anxiety, etc.. I have been taking these two for about four years now, and these are the dosages: in the morning I take 100mg of Wellbutrin and .25 of Clonazepam. I take small amounts of the latter since even though it is an anti-anxiety drug and relaxant, it can intensify my restless legs. Therefore, I don't take it in the afternoon or at night. The prescribing doctor suggested I take it during the night to help with sleep, but I've tried that, and while it did make me drowsy, it still made RLS difficult, which resulted in me walking around trying to relieve restlessness with legs and being tired enough that I would nod off while walking. THAT didn't work well as I walked into walls, chairs, etc. during those times & woke up abruptly (and sometimes painfully). I know many people take larger amounts of Clonazepam for anxiety, but I would start out with small doses. I tend to be sensitive to medications, so I always do that anyway. If you notice you're needing to take greater and greater amounts to get the desired results, I'd recommend talking to your doctor about a substitute. There are several drugs in the same family as clonazepam: lorazepam, diazepam, alprazolam and flurazepam. It's possible one of those might work as well. Good luck. I hope this helps.