Yes. I've been on the "big 3" since January 2018. It did keep my condition from getting worse I believe or at least slow it down but that's it. I have a 10 cm. cavity in my upper left lobe of my lung which was supposed to be removed surgically this past Wednesday. However I was hospitalized for over a week in December with pneumonia in the right lung. Therefore, surgery postponed and in the meantime adding Amikacin (inhaled) to the big 3. I start the Amikacin tomorrow. (EEEEk - LOL) - See if you can switch to the Rifabutin or one of the other replacement drugs of the Rifampin. The Rifabutin is in the same family but was different for me.