I am now focused on the component of the Shingrix vaccine which may be responsible for developing my Small Fiber Neuropathy. The Medicinal ingredients are: "1 dose (0.5 mL) contains 50 micrograms of glycoprotein E (gE) powder mixed with AS01B adjuvant suspension. gE is a protein found in the Varicella Zoster Virus. This protein is not infectious." "Non-medicinal ingredients: Cholesterol, dipotassium phosphate, dioleoyl phosphatidylcholine, disodium phosphate anhydrous, polysorbate 80, potassium dihydrogen phosphate, sodium chloride, sodium dihydrogen phosphate dihydrate, sucrose and water for injections."

I believe the culprit is the Adjuvant. "There are several possible pathophysiologic mechanisms that may explain vaccine-associated polyneuropathies including including immune-mediated hypersensitivity to the adjuvants or solvents in the vaccine, as well as nervous system invasion caused by prolonged, less virulent, viral infection." "The adjuvant is made of 50 micrograms each of a plant extract (Quillaja saponaria Molina, fraction 21 (QS-21)) and a bacterial extract (3-O-desacyl-4’- monophosphoryl lipid A (MPL)) and is used to improve your body’s response to the vaccine." This is reported to be a very powerful adjuvant.

My questions are: 1. How long does this adjuvant stay active in the body? 2. Can it be neutralized? 3. What is the mechanism causing the neuropathy?
4. What component in the adjuvant is the source of the problem?

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