@albiet, it's always a good idea to run any supplements by your doctor or pharmacist especially if you are taking any medications. The supplements I take which R-ALA and Acetyl L-Carnitine are included are at therapeutic levels to provide cellular level nutrition for the nerves. It has helped me slow and stop the progression of my small fiber PN based on my numbness symptoms.

@albiet Hi, I'm brand new to this Mayo group, diagnosed with 'Small Fiber Neuropathy with Autonomic Involvement' in 2016. At least my neurologist's nurse said: "Your notes indicate this is the nearest diagnosis that matches your symptoms at this time". Since then, the stinging and burning pain is spreading from both buttocks (worst pain which prevents me from sitting for more than a few minutes and has destroyed my social life and travel) to all limbs, face and eyes. You ask about supplements so what I can say is, along with other things I do, being a Nutritarian partly involves taking supplements and my physician, who supervises this, assures me that along with the other health benefits being Nutritarian slows the progress of the disease.