I tried the morning and night routines as suggested, and I was miserable. Talked to my doc, and he said the best time is what works for you, so that you will take them every time. So I take mine at bedtime after a light snack, and any queasiness, headache, etc happen during the night - disturb my sleep a little but not disabling all day. I need to be in good shape during the days as I help my daughter care for a preemie & a toddler. If I was taking the meds in the morning as advised, I felt sick all day - no help at all to her, and tempted to skip them every time something was scheduled on a med day. We'll see if this is "good enough" - waiting on results of repeat sputum culture.