I'm taking 12.5 mg Metoprolol twice a day and am watching for any symptoms.(It's only been a month) I'm not a firm believer in DOCTOR KNOWS ALL...if I had symptoms I didn't like I would totally refuse to take the medicine. My local doctor hints I have TOO MUCH say in my treatment but it's up to US to know our bodies and do the research. There ARE other options and I personally think it's foolish to make my health worse by taking a certain Rx.