Yes. Have a script for linaclotide, think its called linzess in U.S. Took it some time ago and it gave me so much pain, I'm afraid to try it again. Over the counter laxatives work, but I have developed adverse reactions to some of those. Then there is prucalopride, in Canada called Resotran. Really do not want to take that because Health Canada warns patients with arrythmias to proceed with caution. May go back to senna and have referral to see gastroenterologist again.