Hello, I take metoprolol two times a day when I wake up and at bedtime. Started with 25mgs and now it is 50mgs. For about five years now. I do have sleep issues. Cannot seem to get enough sleep, however I am 81 years of age. But, I also take Cartia 100 mgs in the am and take Losarten 100mgs at night. This is for murmer and irregular heart beat for to fast a beat. It does pretty good for me. Hope this helps you. peach