A previous doctor prescribed the bp meds 12 hours apart and that seems to have kept the pressure under control. The routine is Atenolol at 6 a.m. followed by eye drops Brimonidine and then 1 p.m and 9 p.m. The next one, Tomolol after 6:05 a.m. The third one. Zioptan. after 9:05 pm followed afterward by eye lubricant to keep the eye moist during sleep. I guess there might be some interaction between the bp med and eye drops but I am only aware of it in the morning.