Dry mouth and throat are my enemies as I have suffered from that for years and had to have thousands of $$$ in dental work done. Yes, feel drier and like I have a mouth and throat full of glue and I know the Zofran isn't helping. I switched to trying just the Tigan and it is not as bad. I constantly have to drink something, chew Act gum, use Biotene soray, etc. Actually, yesterday, I felt somewhat better but maybe did too much. Went for my blood work and decided to go to a wig salon here in town. Had intended to just look but I did buy a wig. My husband was very patient thru the whole thing, shocking. LOL! I then got a Big Mac and ate the whole thing. Most I had eaten in days. I have lost about 8 lbs but starting out with a few extra to spare. Now, to address constipation probkems which sent me to Stanford some years ago.