I'm 71 and have had dysthymia(constant low grade depression)for at least 30 or more years. I have had issues of late, and changed medications twice. Tried trintillix, and it was not good for me. It is expensive, but when it works, it is the holy grail. Changed to Prozac about ten days ago, and some Klonopin for anxiety/sleep. Slept for 9 hours last night after a long bout of insomnia. It's a crapshoot to get the chemistry correct. Just be sure you have a doctor who will work with you.