@drpepper I’ve been taking Xifaxan for just over a year and a half. It’s something my insurance will not cover without an accompanying Lactulose prescription. My hepatologist says it works better than lactulose, but hey it’s so expensive I’m happy to take the lactulose too.

@kanaazpereira @drpepper I took xifaxan for hepatic encephalopathy (HE). I had cirrhosis and that can cause HE episodes. I was first on lactulose but it really bothered my stomach so when I saw the hepatologist she prescribed xifaxan. I took just that, no lactulose, for almost a year and had no problems, no HE episodes. It was like an answer to a prayer. Then I had another episode. It may have been due to a couple of things occurring that can contribute to bringing on an HE episode but it also could have meant that my cirrhosis had progressed so I had to resume taking lactulose along with the xifaxan. About 6 months after that I had a liver transplant so thankfully no need for either any more.
When I was taking xifaxan the doctor prescribed two a day, I believe they were 550 mg each. The retail on that was around $2400 at the time, I have heard it is a bit less now. With my insurance, I paid between $700 and $800 a month for it.
It is an antibiotic of sorts so I would think it could help with SIBO but I am not a medical person or a pharmacist so I really can't comment on that. I did google SIBO and xifaxan and some of the links said that was the was the first way to treat SIBO but one article said it was not. It's worth looking it up yourself.
JK