I just started on trintellix and I feel so much better with my depression and anxiety like in the first week. This is like a miracle drug for me after being so depressed and trying everything and always ending up with prozac with j was suicidal still. I am dealing with the nausea that comes for the beginning and should be subsiding. I’m also taking zofran for that. For me it is worth it when the nausea goes away after the first few weeks because I haven’t cried since the day I started and I’m showering and doing little by little. My depression becomes that debilitating and ptsd anxiety agoraphobia. I think this is the best one I’ve taken and I’ve taken them all.