← Return to Switching to Trintellix or Low Dose Naltrexone (LDN)

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@lisalucier

Hi, @petangelkat1 – welcome to Mayo Clinic Connect. Seems wise to ensure you are taking your new medication, the vortioxetine (Trintellix), in the best possible way.

I've not taken this particular antidepressant, so can't speak from experience. I will mention, however, that when I started bupropion (Wellbutrin) years ago a pharmacist I asked indicated I'd need to wait 2-3+ months to really settle into it and see how it worked for me.

I'd like to bring into this conversation a few members who have mentioned this antidepressant and may have insights related to the timing of taking the medication and how long it might be to take to effect. Please meet @karen00 @beckysn @ronniekep @nansmith @depressionsurvivor @bipolar4ever. @gailb may also have some thoughts for you.

@petangelkat1 – along with the interaction with other patients who have taken vortioxetine (Trintellix), is there a pharmacist where you filled your prescription who might advise you on these questions? Or, would your prescribing doctor's staff have any input on this for you?

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Replies to "Hi, @petangelkat1 - welcome to Mayo Clinic Connect. Seems wise to ensure you are taking your..."

My physician has changed me from trintillix to Prozac. I have yet to take the Prozac as I don’t know when to take it. Two capsules daily is a bit ambiguous, and I have a call in. I had been taking trintillix the last thing at night, and I slept 8.5 hours straight through. Did the same tonight and it is 4 a.m., and I’m still awake. I made a bad decision to try to squeeze some sleep from trintillix, and I’m paying for it. The switch to Prozac is represented to be less eventful, but I am not pleased. I think I’m going to wait a day before changing to Prozac since the half life of trintillix is about 60 hours. I believe my system isn’t handling the buildup of the medication. Darn, I felt so good today with a good nights sleep. It will happen again. I’m just wired.

My physician switched me to Prozac. Easier transition. Said I was the first patient he had on trintillix who had suicidial ideation. Trintillix is either wonderful or it is not wonderful. I am in the latter group.