Hi, @petangelkat1 – welcome to Mayo Clinic Connect. Seems wise to ensure you are taking your new medication, the vortioxetine (Trintellix), in the best possible way.
I've not taken this particular antidepressant, so can't speak from experience. I will mention, however, that when I started bupropion (Wellbutrin) years ago a pharmacist I asked indicated I'd need to wait 2-3+ months to really settle into it and see how it worked for me.
@petangelkat1 – along with the interaction with other patients who have taken vortioxetine (Trintellix), is there a pharmacist where you filled your prescription who might advise you on these questions? Or, would your prescribing doctor's staff have any input on this for you?