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Switching to Trintellix or Low Dose Naltrexone (LDN)

Depression & Anxiety | Last Active: Jan 8, 2022 | Replies (59)
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@petangelkat1

I’m taking Duloxetine and Trintellux together. Trintellix was added to my arsenal about 1 month ago. I’m on a low dosage of 10mg. I too have been taking Triintellix in the morning but wonder how f night time is best. I started off at 5 mg but can’t really tell that it’s working. I’ve not really noticed any side effects. Any ideas out there? I take 90mg of Dulixetine and have for years. I’m wondering how long it typically takes for the Trintellix to take effect if I s going to be affective for me.

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Replies to "I’m taking Duloxetine and Trintellux together. Trintellix was added to my arsenal about 1 month ago...."
Lisa Lucier, Moderator | @lisalucier | Jan 2, 2019

Hi, @petangelkat1 - welcome to Mayo Clinic Connect. Seems wise to ensure you are taking your new medication, the vortioxetine (Trintellix), in the best possible way.

I've not taken this particular antidepressant, so can't speak from experience. I will mention, however, that when I started bupropion (Wellbutrin) years ago a pharmacist I asked indicated I'd need to wait 2-3+ months to really settle into it and see how it worked for me.

I'd like to bring into this conversation a few members who have mentioned this antidepressant and may have insights related to the timing of taking the medication and how long it might be to take to effect. Please meet @karen00 @beckysn @ronniekep @nansmith @depressionsurvivor @bipolar4ever. @gailb may also have some thoughts for you.

@petangelkat1 - along with the interaction with other patients who have taken vortioxetine (Trintellix), is there a pharmacist where you filled your prescription who might advise you on these questions? Or, would your prescribing doctor's staff have any input on this for you?

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