I am presently taking daily, in split dosage, 7.5mg. I am carefully monitoring myself, but have to say to myself, "every pain in your body is not necessarily caused by PMR." I do have osteoarthritis in my lower back/hips and somewhat in my hands. I had a restless night last night, my tendency was to think caused by PMR. However, it could have been that I had a very lazy afternoon reading for hours, and was already rested. So will continue on the usual dosage, not "up" it.