Hello @meka, you may find some of the conversations in the Visiting Mayo Clinic group helpful, https://connect.mayoclinic.org/group/traveling-to-mayo-clinic/. I recently shared a PDF map with another member wondering about what hotels were connected to the downtown Rochester Mayo Clinic campuses. Here is what I posted:

Almost any hotel in downtown Rochester has access to downtown Mayo Clinic buildings via subway or skyway. Here are a few specific ones:

– Marriott Residence Inn
– Kahler Inn & Suites
– Hilton
– Rochester Marriott Hotel

Here is a link to the campus map, which includes a map of the subway system, https://www.mayo.edu/pmts/mc1600-mc1699/mc1663-55.pdf?_ga=2.60956907.67298372.1546544292-1675055088.1541027282.