I tried Linzess only once about a year and a half ago. Only two capsules. It worked (and its effects continued into the next week), however it gave me awful bloating and pain (enough that I couldnt sleep). So, I am nervous about trying it again. Someone on Mayo Clinic Connects mentioned a 70 mg dose which sounds like 1/2 of the standard dosage. Will ask the gastroenterologist if that's a possibility (if available in Canada in the lower dosage). So far, the Senokot is causing the least amount of trouble but who knows. I have a long history of adverse drug reactions.