Hi, @bonnieboo – Welcome to Mayo Clinic Connect. As you mentioned you will be having a hysterectomy with bilateral salpingo-oophorectomy and will go into menopause — yet are allergic to oestrogen/estrogen and progesterone and cannot take hormone replacement therapy (HRT) — it makes sense you’d be looking for appropriate alternatives.

CBD isn't a replacement for HRT, but rather a substance that is being investigated as having potential to alleviate symptoms of menopause. I found one article talking about research along these lines https://www.medicalnewstoday.com/articles/322078.php. You’ll note in the “Takeaway” section of the article it says, “At present, there is very little reliable evidence to suggest that CBD oil can treat the symptoms of menopause.”

Here are some Mayo Clinic resources that discuss alternatives to HRT:

- A discussion in-depth on HRT, including a section about “What Can You Do If You Can’t Take Hormone Therapy?”
https://www.mayoclinic.org/diseases-conditions/menopause/in-depth/hormone-therapy/art-20046372
- Information on non-HRT treatment for the signs and symptoms of menopause, listed in the Treatment, Lifestyle and Home Remedies, and Alternative Medicine sections of this article on Menopause https://www.mayoclinic.org/diseases-conditions/menopause/diagnosis-treatment/drc-20353401

I’d like to invite additional Connect members who have mentioned menopause into this discussion to talk about any alternatives to HRT they may have used to manage menopause symptoms, like @mang133 @windwalker @cindylb @kathleentischer @catherinelewis and @jenniferhunter.

@bonnieboo, what has your gynecologist suggested for an HRT alternative, given your allergy?