That is a tough choice. Whatever you decide, it must be what is comfortable fro you. What does this new trial offer? Yes you could be one who gets the new medicine, or one who does not.Does the new medicine offer to completely remove the glioblastoma If you didn't get the medicine, can you easily go back on the high dose of temozolomide? Whatever you decide, keep on posting here and know you are in my thoughts and prayers.