I've shared this before on this site but I went through 4 bouts of Cdiff in 2018 after taking Clindamycin. I took Flagyl after the first bout. Then I took Vancomycin for the 2nd and 3rd bouts. I even did the pulse and taper with Vanco for the 3rd bout. Nothing worked for me until I took Dificid (fidaxamycin) for the 4th and final bout. That's the RX that cured my Cdiff. I now take Florastor or any type of S. Boulardii brand daily and have been taking it since 2018 when my gastroenterologist recommended it. I had a UTI last month and was a nervous wreck being on an antibiotic (Macrobid) for 5 days and them Flagyl for a week. I was scared to death that Cdiff would return. That was one month ago and so far, I'm fine. I knock on wood whenever saying that. I wish more doctors would prescribe Dificid after a second Cdiff occurrence instead of putting patients through so much pain and suffering. I know it's expensive but it works. I have another friend who was given it after her 2nd bout of Cdiff. I'm thankful every day that she told me about it working for her.