@debminuet I have been taking the big 3 daily since July. I’m also taking Arikayce daily. They are all a worry. But......so is the infection. My infectious disease doctor told me that if you were to give these drugs to a well person they would be very sick......so my question to him was.....if we are getting well and feel bad.....shouldn’t we stop the drugs because we are more well than sick and the drugs are making us feel lousy. His answer to me was no.....the biggest mistake is getting off the drugs too early.....MAC must be completely irradiated before the drugs are stopped....that’s why they have us on them 6 months after we have a negative sputum culture.