To@marilynk….I started Arikayce on Nov 12 and have been on the Big 3 for six months. I’ve had a sore throat and have had emotional ups and downs. I too am very concerned about the serious side effects. Being on any kind of medication for a long period of time is tough on us….but so is this disease. I am vigilant following all the instructions and getting periodic eye and ear and blood check ups. The troubling thing I find is how little doctors know about this drug….and their lack of experience with patients taking it. Still I plan to continue with it unless side effects become overwhelming. Id like to hear from everyone taking Arikayce…we can be a great help to each other!